FinancialBuzz.com’s latest Behind the Buzz Show: Featuring Our Corporate Overview on INmune Bio Inc.
INmune Bio, Inc. (NASDAQ: INMB), a clinical-stage biotechnology company focused on developing treatments that target the innate immune system to fight disease. INmune Bio has two product platforms. The DN-TNF product platform utilizes dominant-negative technology to selectively neutralize soluble TNF, a key driver of innate immune dysfunction and mechanistic target of many diseases. DN-TNF is currently being developed for cancer (INB03), Alzheimer’s (XPro595), and NASH (NeuLiv). The Innate Immune Priming Platform includes INKmune aimed at priming the patient’s NK cells to eliminate minimal residual disease in patients with cancer. INmune Bio’s product platforms utilize a precision medicine approach for the treatment of a wide variety of hematologic malignancies, solid tumors and chronic inflammation.
Cancer is among the leading causes of death in the world as countries are burdened by a lack of access to adequate healthcare. In 2018, the World Cancer Research Fund (WCRF) estimated that there were 18 million new cancer cases worldwide. Among these 18 million, 9.5 million were men and 8.5 million were women, while the most commonly diagnosed cancers were lung, breast, and colorectal. In particular, the top three diagnosed cancers accounted for over a third of total global cases. Most cases of cancer result from risk factors such as poor diet, nutrition, and physical condition. However, in some instances, cancer can be caused by hereditary factors such as genetics or environmental impacts. The WCRF mentioned that roughly 40% of cancer cases in 2018 could have been prevented if patients had a more well-rounded diet. Nonetheless, the number of cases is gradually rising, prompting pharmaceutical and biotechnology companies to develop innovative treatments. The cancer treatment market is a large sector due to the various methods and techniques companies choose to employ. For instance, chemotherapy is one of the most popular cancer treatments that uses anti-cancer drugs to either cure cancer, prolong life expectancy, or reduce symptoms. On the other hand, radiotherapy is another popular treatment that is aimed at controlling or eliminating malignant cells. Notably, immunotherapies have also become increasingly popular among cancer patients. Immunotherapy harnesses the patient’s immune system in order to fight against the cancer. Additionally, immunotherapy also helps the body fight against other infections and diseases. And according to data compiled by Grand View Research, the cancer immunotherapy market is projected to reach USD 126.9 Billion by 2026 while exhibiting a CAGR of 9.6% during the forecast period.
Immunotherapy can be used to treat other diseases such as Alzheimer’s, however, it is most commonly associated with cancer treatment. Immunotherapy works by boosting the immune system, which allows the body to detect and destroy abnormal cells. Furthermore, the therapy also prevents and curbs the growth of other cancers from developing. There are several types of immunotherapies such as immune checkpoint inhibitors, T-cell transfer therapy, monoclonal antibodies, vaccines, and immune system modulators, according to the National Cancer Institute. Vaccines and T-cell transfer therapy focus on boosting the immune system and the T-cell’s ability to fight against cancer. On the other hand, immune checkpoint inhibitors are drugs used to block immune checkpoints, which allows immune cells to better respond to cancer cells. Additionally, monoclonal antibodies are proteins created to bind to specific targets on the cancer cells themselves. In some instances, monoclonal antibodies will mark cancer cells, allowing the immune system to better detect and ultimately destroy them. Although immunotherapy is not as popular as chemotherapy, radiotherapy, or surgery, it is becoming an increasingly popular cancer treatment method among patients. “In 2018, there were over 900 new cancer immunotherapies in development, with over 5,000 clinical trials investigating these agents and more than half a million patients being treated with these agents,” said Leonard H. Calabrese, DO, Vice Chairman of rheumatic and immunologic disease, at the Cleveland Clinic at the Seventh Annual Basic and Clinical Immunology for the Busy Clinician symposium. “Immunotherapy is now a pillar of cancer treatment — it is now ensconced as a part of this therapy.”
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