International Stem Cell Corporation (OTCQB: ISCO), a California-based clinical stage biotechnology company developing novel stem cell-based therapies and biomedical products, announced today that a paper prepared by the Company has been published in Volume 12, Issue 5 of the Journal of Tissue Engineering and Regenerative Medicine, a prestigious peer-reviewed scientific journal. Due to its scientific relevance, the article has been featured on the cover of the journal’s May 2018 issue.
The article, entitled “Supplementation of Specific Carbohydrates Results in Enhanced Deposition of Chondrogenic-Specific Matrix during Mesenchymal Stem Cell Differentiation,” discusses a new scalable system developed by ISCO that permits the generation of functional human cartilage tissue derived from the patient’s own skin or fat tissue. This process has the capacity to provide greater stability than other tissue that is currently available for the treatment of osteoarthritis, the most common chronic joint condition.
Using this new system, ISCO scientists generated a healthy cartilage?specific matrix from human mesenchymal stem cells that had significantly higher viability and cartilage specific properties, including: proteoglycan, aggrecan, hyaluronic acid, and collagen II deposition and glycosaminoglycan production. This new cartilage-specific matrix was built in 3D format and is ready for further therapeutic development.
“While the treatment of Parkinson’s disease has always been at the forefront of our research efforts, we are also pursuing various other therapeutic indications. In one of those other areas,our R&D Team has significantly improved the process by which we can use the patient’s own mesenchymal stem cells to potentially treat osteoarthritis,” commented Russell Kern, PhD, ISCO’s Executive Vice President and Chief Scientific Officer. “We are also thrilled to announce that this research gives us a basis to launch program to develop supplements designed to potentially reduce joint pain and improve overall mobility,” he continued.
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