Synthetic Lethality-based Drugs & Targets World Market, Forecast to 2030 by Type of Molecules, Different Target Indications, Synlet Targets, Route of Administration, and Key Geographical Regions | Financial Buzz

Synthetic Lethality-based Drugs & Targets World Market, Forecast to 2030 by Type of Molecules, Different Target Indications, Synlet Targets, Route of Administration, and Key Geographical Regions

Dublin, Jan. 09, 2020 (GLOBE NEWSWIRE) — The “Synthetic Lethality-based Drugs and Targets Market, 2019-2030: Focus on DNA Repair (including PARP Inhibitors) and Other Novel Cellular Pathways” report has been added to’s offering.

Currently, there are four approved (and marketed) poly-ADP ribose polymerase (PARP) inhibitor drugs, which have been shown to operate based on the concept of synthetic lethality. Further, several such drugs are being investigated for the treatment of a myriad of advanced oncological and non-oncological indications. A number of companies are engaged in this domain; moreover, both venture capital (VC) firms and government bodies are actively funding such research initiatives.

This report features an extensive study of the current market landscape and the future potential of the synthetic lethality-based therapeutics. It features an in-depth analysis, highlighting the capabilities of various companies engaged in this domain.

One of the key objectives of the report was to estimate the existing market size and identify the future opportunity for synthetic lethality-based drugs, over the next decade. Based on multiple parameters, such as target consumer segments, region-specific disease prevalence, anticipated adoption of the marketed and late stage drugs and the likely selling price, we have provided informed estimates on the evolution of the market over the period 2019-2030. The report includes potential sales forecast of drugs that are currently marketed or are in late stages of development (phase II and above).

The report also features the likely distribution of the current and forecasted opportunity across

  • [A] type of molecules (small molecule and biologic)
  • [B] different target indications (breast cancer, colorectal cancer, fallopian tube cancer, gastric cancer, head and neck cancer, lung cancer, ovarian cancer, peritoneal cancer and others)
  • [C] synlet targets (APE1 / Ref-1, Chk1, GLS1, PARP, Pol , PP2A and Wee1)
  • [D] route of administration (oral and intravenous)
  • [E] key geographical regions (North America, EU5, Asia-Pacific and Rest of the World)

To account for the uncertainties associated with the growth of synthetic lethality-based drugs market and to add robustness to our model, we have provided three market forecast scenarios, namely conservative, base and optimistic scenarios, representing different tracks of the industry’s growth.

In addition to other elements, the study includes:

  • A detailed assessment of the current market landscape, providing information on drug developer(s) (year of establishment, headquarters and size of the company), phase of development (marketed, clinical, preclinical, and discovery stage) of lead candidates, type of molecule (small molecule and biologic), type of therapy (monotherapy and combination therapy), type of synlet target, target patient segment, key therapeutic area(s), target indication(s), and route of administration. In addition, the chapter includes a list of screening platforms that are being used by industry players to study synlet interactions between gene pairs.
  • Detailed profiles of large players that are engaged in the development of synthetic lethality-based drugs (shortlisted on the basis of phase of development of pipeline products), featuring a brief overview of the company, its financial information (if available), detailed profiles of their respective lead drug candidates, and an informed future outlook. Additionally, each drug profile features information on the type of drug, route of administration, target indications, current status of development and an excerpt on its developmental history. In addition, the chapter includes tabulated profiles of small-sized and mid-sized players (shortlisted on the basis of the number of pipeline products), featuring details on the innovator company (such as location of headquarters, year of establishment, number of employees, and key members of the executive team), recent developments, along with descriptions of their synthetic lethality-based drug candidates.
  • An analysis of the prevalent and emerging trends in this domain, as represented on the social media platform, Twitter, posted during the period 2010-2019 (till May), highlighting the historical trend of tweets, most prolific contributors, frequently discussed synlet targets, popular disease indications and a multivariate tweet benchmark analysis.
  • An analysis of close to 700 peer-reviewed scientific articles related to synthetic lethality, published during the period 2017-2019 (till May), highlighting the research focus within this niche industry segment. It includes an informed opinion on the key trends observed across the aforementioned publications, including information on target disease indications, synlet targets, and analysis based on various relevant parameters, such as study type (review article, research article and case report), research objective, year of publication, key research hubs, most popular authors, provision of grant support, and most popular journals (in terms of number of articles published in the given time period and journal impact factor).
  • An analysis of various abstracts presented at the American Society of Clinical Oncology (ASCO) in the time period 2013-2019 (till May), highlighting several parameters, such as year of (abstract) publication, popular drugs, synlet targets, target cancer indications, popular authors, author designations, industry type (industry and academia) and most active organizations (in terms of number of published abstracts). In addition, this analysis features a multi-dimensional bubble chart analysis to assess the relative level of expertise of the key authors / researchers based on the number of publications, citation count and research gate score.
  • An in-depth analysis of close to 750 grants that have been awarded to research institutes engaged in projects related to synthetic lethality, between 2014 and 2019 (till May), highlighting various important parameters associated with grants, such as year of award, support period, amount awarded, funding institute, administration institute center, funding institute center, funding mechanism, spending categorization, grant type, responsible study section, focus area, type of recipient organization and prominent program officers. It also features a detailed analysis on most popular synlet targets and target indications, along with a multivariate grant attractiveness analysis based on parameters, such as amount awarded, support period, grant type, number of synlet targets and number of indications under study.
  • An analysis of the investments made into companies that have proprietary synthetic lethality-based drugs / screening platforms, including seed financing, venture capital financing, debt financing, grants, capital raised from IPOs and subsequent offerings.
  • An in-depth benchmark analysis of over 230 synlet targets identified from various credible sources (research publications, government fundings, clinical studies, recent news / tweets and abstracts presented in global conferences), highlighting targets that have already been validated in clinical studies, preclinical studies and early-stage research (cases where there is no lead (therapeutic) candidate being investigated). Further, it highlights the long-term opportunities (for drug developers) associated with individual targets, based on their popularity across different portals.
  • An analysis of the role of innovative companion diagnostics in synthetic lethality on the basis of several parameters, such as synlet target, drug candidate(s) being investigated, target biomarker(s), target disease indication(s) and assay technique used. It also includes case studies, highlighting those companion diagnostic tests that are available and are being used to evaluate the therapeutic efficiency of approved PARP inhibitors using the principle of synthetic lethality.

Key Topics Covered

1.1. Scope of the Report
1.2. Research Methodology
1.3. Chapter Outlines


3.1. Chapter Overview
3.2. Overview of Deoxyribonucleic Acid (DNA) Damage
3.3. DNA Damaging Agents
3.3.1. Endogenous DNA Damaging Agents
3.3.2. Exogenous DNA Damaging Agents
3.3.3. Other DNA Damaging Agents
3.4. DNA Damage Response System
3.4.1. Key Components of DNA Repair System
3.5. Types of DNA Repair Systems
3.5.1. Direct Repair
3.5.2. Excision Repair
3.5.3. Indirect Repair
3.6. Mutations in DNA Repair Genes

4.1. Chapter Overview
4.2. Concept of Synthetic Lethality
4.2.1. Historical Evolution of Synthetic Lethality
4.2.2. HRR and Synthetic Lethality
4.2.3. Other Synthetic Lethal Gene Interactions
4.2.4. Gene Interactions beyond Synthetic Lethality
4.2.5. Applications of Synthetic Lethality
4.2.6. Limitations of Synthetic Lethality
4.3. Identification of Synlet Interactions
4.3.1. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) Based Synlet Target Identification
4.3.2. RNA Interference (RNAi) Based Synlet Target Identification
4.3.3. Other Screening Platforms for Synlet Target Identification
4.4. Prevalent Trends Related to Synthetic Lethality
4.4.1. Recent News on Google: Emerging Focus Areas
4.4.2. Google Trends Analysis: Historical Timeline
4.4.3. Google Trends Analysis: Geographical Activity
4.4.4. Google Trends Analysis: Co-Relation with Other Therapeutic Areas
4.5 Concluding Remarks

5.1. Chapter Overview
5.2. Synthetic Lethality-based Drugs: Marketed and Development Pipeline
5.2.1. Analysis by Phase of Development
5.2.2. Analysis by Type of Molecule
5.2.3. Analysis by Type of Therapy
5.2.4. Analysis by Type of Synlet Target
5.2.5. Analysis by Type of Patient Segment
5.2.6. Analysis by Therapeutic Area
5.2.7. Analysis by Target Indication
5.2.8. Analysis by Route of Administration
5.3. Synthetic Lethality-based Drugs: List of Drug Developers
5.3.1. Analysis by Year of Establishment
5.3.2. Analysis by Location of Headquarters
5.3.3. Analysis by Company Size
5.3.4. Analysis by Company Size and Location of Headquarters

6.1. Chapter Overview
6.2. Profiles of Established Players
6.2.1. AbbVie
6.2.2. AstraZeneca
6.2.3. BeiGene
6.2.4. Clovis Oncology
6.2.5. GlaxoSmithKline
6.2.6. Pfizer
6.3. Profiles of Small and Mid-Sized Players
6.3.1. AtlasMedx
6.3.2. Chordia Therapeutics
6.3.3. IDEAYA Biosciences
6.3.4. Mission Therapeutics
6.3.5. Repare Therapeutics
6.3.6. Sierra Oncology
6.3.7. SyntheX Labs

7.1. Chapter Overview
7.2. Scope and Methodology
7.3. Synthetic Lethality: Trends on Twitter
7.3.1. Cumulative Year-Wise Activity
7.3.2. Historical Trends in Volume of Tweets
7.3.3. Evolutionary Trend Analysis
7.3.4. Trending Words / Phrases on Twitter
7.3.5. Most Prolific Contributors on Twitter
7.3.6. Most Popular Synlet Targets / Patient Mutations on Twitter
7.3.7. Most Popular Indications on Twitter
7.3.8. Heat Map Analysis: Distribution by Synlet Targets / Patient Mutations and Indications
7.4. Most Popular Tweets
7.5. Concluding Remarks

8.1. Chapter Overview
8.2. Scope and Methodology
8.3. Synthetic Lethality: List of Recent Publications, 2019
8.3.1. Analysis by Type of Publication
8.3.2. Analysis by Study Objective
8.4. Synthetic Lethality: Publication Analysis, 2017-2019
8.4.1. Analysis by Year of Publication
8.4.2. Emerging Focus Areas
8.4.3. Analysis by Synlet Targets / Patient Mutations Most Popular Synlet Targets / Patient Mutations Year-Wise Trend in Activity for Popular Synlet Targets / Patient Mutations
8.4.4. Analysis by Target Indications Most Popular Target Indications Year-Wise Trend in Activity for Popular Target Indications
8.4.5. Analysis by Key Research Journals Key Journals Based on Number of Publications Analysis by Journal Impact Factor Key Journals Based on Journal Impact Factor
8.4.6. Key Research Hubs
8.4.7. Most Popular Authors
8.4.8. Analysis of Publications with Grant Support Most Popular Grant Bodies Location of Grant Bodies
8.5. Publication Benchmark Analysis

9.1. Chapter Overview
9.2. Scope and Methodology
9.3. Synthetic Lethality: List of American Society of Clinical Oncology Abstracts
9.3.1. Analysis by Year of Publication
9.3.2. Emerging Focus Areas
9.3.3. Most Popular Drugs
9.3.4. Most Popular Synlet Targets / Patient Mutations
9.3.5. Most Popular Target Indications
9.3.6. Most Popular Principal Authors Analysis by Locations of Principal Authors Analysis by Industry Type of Principal Authors Analysis by Active Organization Analysis by Author Designation Most Popular Authors

10.1. Chapter Overview
10.2. Scope and Methodology
10.3. Synthetic Lethality: List of Grants Awarded by National Institutes of Health
10.4. Grant Attractiveness Analysis

11.1. Chapter Overview
11.2. Types of Funding
11.3. Synthetic Lethality: List of Funding and Investments
11.4. Concluding Remarks

12.1. Chapter Overview
12.2. Scope and Methodology
12.3. Target Benchmark Analysis
12.3.1. Clinically Validated Synlet Targets
12.3.2. Preclinically Validated Synlet Targets
12.3.3. Early Stage Research Validated Synlet Targets
12.4. Initiatives of Big Pharmaceutical Players
12.5. Concluding Remarks

13.1. Chapter Overview
13.2. Concept of Companion Diagnostics
13.3. Development of Companion Diagnostics
13.4. Advantages of Companion Diagnostics
13.5. Applications of Companion Diagnostics in Synthetic Lethality
13.6. Companion Diagnostics: List of Available / Under Development Tests
13.6.1. Analysis by Synlet Target
13.6.2. Analysis by Type of Biomarker
13.6.3. Analysis by Type of Biomarker and Technology
13.6.4. Analysis by Target Indication
13.6.5. Analysis by Developer and Synlet Target
13.6.6. Most Prominent Developers
13.7. Case-in-Point: Companion Diagnostics for Commercially Available Poly-ADP Ribose Polymerase (PARP) Inhibitors
13.7.1. Companion Diagnostics Test for Niraparib
13.7.2. Companion Diagnostics Test for Olaparib
13.7.3. Companion Diagnostics Test for Rucaparib
13.7.4. Companion Diagnostics Test for Talazoparib
13.8. Future Perspective

14.1. Chapter Overview
14.2. Scope and Limitations
14.3. Forecast Methodology and Key Assumptions
14.4. Overall Synthetic Lethality-based Drugs Market, 2019-2030
14.4.1. Synthetic Lethality-based Drugs Market: Distribution by Type of Molecule, 2019-2030
14.4.2. Synthetic Lethality-based Drugs Market: Distribution by Synlet Target, 2019-2030
14.4.3. Synthetic Lethality-based Drugs Market: Distribution by Target Indication, 2019-2030
14.4.4. Synthetic Lethality-based Drugs Market: Distribution by Route of Administration, 2019-2030
14.4.5. Synthetic Lethality-based Drugs Market: Distribution by Geography, 2019-2030
14.4.6. Product-wise Sales Forecast Niraparib (GlaxoSmithKline) Olaparib (AstraZeneca) Rucaparib (Clovis Oncology) Talazoparib (Pfizer) Pamiparib (BeiGene) Veliparib (AbbVie) Adavosertib (AstraZeneca) AZD6738 (AstraZeneca) APX3330 (Apexian Pharmaceuticals) CB-839 (Calithera Biosciences) CX-5461 (Senhwa Biosciences) LB-100 (Lixte Biotechnology) SRA737-01 (Sierra Oncology) SRA737-02 (Sierra Oncology)
14.4.7. Concluding Remarks


16.1. Chapter Overview
16.2. Artios Pharma
16.3. IMPACT Therapeutics
16.4. Harvard Medical School
16.5. Panjab University
16.6. UbiQ



  • 3W Partners
  • 5AM Ventures
  • 6 Dimensions Capital
  • 8VC
  • Abbott
  • AbbVie
  • AbbVie Ventures
  • Abingworth
  • Adage Capital Partners
  • Adams Street Partners
  • Advanced Technology Ventures
  • Agilent Technologies
  • Agios Pharmaceuticals
  • Alaska Women’s Cancer Care
  • Alexandria Real Estate
  • Alexandria Venture Investments
  • Alex’s Lemonade Stand Foundation for Childhood Cancer
  • Allergan
  • Almac
  • Altitude Life Science Ventures
  • Amadeus Capital Partners
  • American Association for Cancer Research
  • Amherst Fund
  • Amoy Diagnostics
  • Andera Partners
  • Angel Investors
  • Apexian Pharmaceuticals
  • Apjohn Ventures Fund
  • Apollo Munich Health
  • Aptose Biosciences
  • ARCH Venture Partners
  • Arix Bioscience
  • Arkin Holdings
  • Artios Pharma
  • Astellas Ventures
  • AstraZeneca
  • AtlasMedx
  • Atrin Pharmaceuticals
  • Austrian Science Fund
  • Baylor College of Medicine
  • BDC Capital’s Healthcare Venture Fund
  • Beckman Research Institute
  • BeiGene
  • Beth Israel Deaconess Medical Center
  • Biodesix
  • Biogenex Laboratories
  • BioMed Ventures
  • BioMedical Catalyst Fund
  • bioMrieux
  • Biotechnology and Biological Sciences Research Council
  • Boehringer Ingelheim Venture Fund
  • Boston College
  • Boxer Capital of the Tavistock Group
  • Boyu Capital
  • Breast Cancer Now
  • Brigham And Women’S Hospital
  • Broad Institute
  • BVF Partners
  • C4X Discovery
  • Calibr
  • Calico
  • Calithera Biosciences
  • Cambridge Enterprise
  • Canaan Partners
  • Canadian Cancer Society Research Institute
  • Candiolo Cancer Institute
  • Capital Midwest Fund
  • CareNet Group
  • Case Western Reserve University
  • Caxton Alternative Management
  • Cedars-Sinai Medical Center
  • Celgene
  • CellCentric
  • Cellecta
  • Cenova Ventures
  • China Investment & Development
  • China Summit Capital
  • Chordia Therapeutics
  • CITIC Private Equity Funds Management
  • City of Hope National Medical Center
  • Cleveland Clinic Lerner College of Medicine
  • Clovis Oncology
  • Cold Spring Harbor Laboratory
  • Columbia University
  • Columbia University Medical Center
  • Cornerstone Parkwalk Advisors
  • CRT Pioneer Fund
  • CStone Pharmaceuticals
  • Cyteir Therapeutics
  • Daiichi Sankyo
  • Dana-Farber Cancer Institute
  • Decheng Capital
  • Delphi Ventures
  • Driehaus Capital
  • Duksung Women’s University
  • EdiGene
  • eFFECTOR Therapeutics
  • Elevate Ventures
  • Emory University
  • Epic Sciences
  • EpiCypher
  • European Research Council
  • Fast Track Initiative
  • Flagship Ventures
  • Fonds de solidarit FTQ
  • Forward Informatics
  • Foundation Medicine
  • Frazier Healthcare Ventures
  • Fred Hutchinson Cancer Research Center
  • Fresenius Kabi
  • Fund for Scientific and Technological Research
  • Georgetown University
  • GIC
  • Google Ventures
  • Grand Angels
  • Green Pine Capital Partners
  • Guangzhou YUEXIU Industrial Investment Fund
  • Guardant Health
  • Gurdon Institute
  • H&Q Asia Pacific
  • HAIBANG Ventures
  • Harvard Medical School
  • Harvard University
  • Hopen Life Science Ventures
  • Horizon Discovery
  • HuagaiCapital
  • IDEAYA Biosciences
  • Ignyta
  • IMPACT Therapeutics
  • Imperial Innovations
  • Indiana University
  • Indiana Univ-Purdue Univ At Indianapolis
  • IndieBio
  • Innovate Indiana Fund
  • Innovate UK
  • Institute of Cancer Research
  • Institute of Nano Science and Technology
  • IP Group
  • Israel Science Foundation
  • Italian Association for Cancer Research
  • Janus Capital Management
  • Japan Agency for Medical Research and Development
  • Japan Society for the Promotion of Science
  • Johns Hopkins University
  • Jonathan Milner
  • King Star Capital
  • Kyoto University Innovation Capital
  • Leica Biosystems
  • Life Sciences Partners
  • LifeNet Health
  • Lightstone
  • Lilly Asia Ventures
  • Lixte Biotechnology
  • LP. Joining Adage
  • LUNGevity Foundation
  • M Ventures
  • Management
  • Marie Curie Initial Training Network CodeAge project
  • Massachusetts General Hospital
  • Mayo Clinic
  • MD Anderson Cancer Center
  • Merck Ventures
  • Metabomed
  • MetaStat
  • Ministry of Economy and Competitiveness
  • Ministry of Education – Singapore
  • Mission Bay Capital
  • Mission Therapeutics
  • Mitsubishi UFJ Capital
  • Mizuho Capital
  • Moffitt Cancer Center
  • Morgan Noble
  • Morgenthaler Ventures
  • Morphic Therapeutics
  • MPM Capital
  • MS Ventures
  • Mylan
  • Myriad Genetics
  • National Agency for Science and Technology
  • National Cancer Institute
  • National Human Genome Research Institute
  • National Institutes of Health
  • National League Against Cancer
  • National Natural Science Foundation of China
  • National Research Foundation of Korea
  • Natural Science Foundation of Guangdong Province
  • Natural Sciences and Engineering Research Council of Canada
  • Nextech Invest
  • Nippon Venture Capital
  • Northeastern University
  • Novartis Venture Fund
  • Ofinnova Partners
  • Ohio State University
  • ONO Pharma
  • OrbiMed Advisors
  • Oregon Health & Science University
  • Oriza Seed Venture Capital
  • Osage University Partners
  • Panjab University
  • Pangaea Biotech
  • Perceptive Advisors
  • Personal Genome Diagnostics
  • Pfizer
  • Pfizer Ventures
  • Pharmacyclics
  • Phi Life Sciences
  • Philadelphia Center
  • PhoreMost
  • Pontifax Fund
  • Premier Pain and Spine
  • Providence Investment Company
  • Qameleon Therapeutics
  • Qualifying Therapeutic Discovery Project Program
  • RA Capital Management
  • Rainbow Seed Fund
  • Repare Therapeutics
  • Resolution Bioscience
  • Roche
  • Roche Venture Fund
  • Russian Foundation for Basic Research
  • Sakarya University
  • Sanford Burnham Prebys Medical Discovery Institute
  • So Paulo State Foundation
  • SBI Investment
  • Scripps Research Institute
  • Sectoral Asset Management
  • Selvita
  • SEngine Precision Medicine
  • Senhwa Biosciences
  • Sequoia China
  • Shanks Lab
  • Sheba Medical Center
  • Shinsei Capital Partners
  • Sierra Oncology
  • SignalRx Pharmaceuticals
  • Silicon Valley Bank
  • Singapore Ministry of Education
  • Singapore sovereign wealth fund
  • Sloan-Kettering Inst Can Research
  • Sloan-Kettering Institute
  • SMBC Venture Capital
  • Snap Bio
  • Sofinnova Partners
  • SOSV
  • SR One
  • SRI International
  • St George Hospital
  • St. Jude Children’s Research Hospital
  • Stanford University
  • Sungent Bioventure
  • SV Health Investors
  • SV Life Sciences
  • SyntheX Labs
  • Taikang Insurance Group
  • Takeda Venture Investments
  • Tango Therapeutics
  • Technion Research and Development Foundation
  • Temple University
  • Temple University of The Commonwealth
  • Teneobio
  • Terra Mafnum Capital Partners
  • The Column Group
  • The Institute of Cancer Research
  • The Ohio State University
  • The Royal Marsden NHS Foundation Trust
  • Thermo Fisher Scientific
  • Third Rock Ventures
  • Thomas Jefferson University
  • Tizona Therapeutics
  • Touchstone Innovations
  • U.S. Venture Partners
  • uBiome
  • UbiQ
  • UCSF Helen Diller Family Comprehensive Cancer Center
  • University College London Cancer Institute
  • University Hospital Complex of A Corua
  • University Hospital Frankfurt
  • University of Bergen
  • University of California
  • University of Castilla-La Mancha
  • University of Chicago
  • University Of Colorado
  • University of Colorado Denver
  • University of Florida
  • University of Glasgow
  • University of Health Network
  • University of Iowa
  • University of Kansas Cancer Center
  • University of Kansas Medical Center
  • University of Lodz
  • University of Macau
  • University of Miami
  • University of Miami School of Medicine
  • University of Navarra Clinic
  • University of New Mexico
  • University of Oklahoma Health Sciences Center
  • University Of Pennsylvania
  • University of Pittsburgh Cancer Institute
  • University of Rome Tor Vergata
  • University of South Alabama
  • University of Texas
  • University of Washington
  • University of Wisconsin-Madison
  • US Department of Defense
  • US Department of Health and Human Services
  • UT Southwestern Medical Center
  • UTokyo Innovation Platform
  • Vanderbilt University
  • Venrock
  • Versant Ventures
  • Vivo Capital of Palo Alto
  • Voyager Therapeutics
  • Wellcome Sanger Institute
  • Woodford Patient Capital Trust
  • Worldwide Cancer Research
  • WuXi AppTec Ventures
  • WuXi Healthcare Ventures
  • Yale School of Medicine
  • Yale University
  • Yunfeng Capital

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